Open AccessHigh Levels of Serum IgG for Opisthorchis viverrini and CD44 Expression Predict Worse Prognosis for Cholangiocarcinoma Patients after Curative Resection
Author(s) -
Attapol Titapun,
Vor Luvira,
Tharatip Srisuk,
Apiwat Jareanrat,
Vasin Thanasukarn,
Malinee Thanee,
Prakasit Sa-Ngiamwibool,
Sureerat Padthaisong,
Kassaporn Duangkumpha,
Manida Suksawat,
Watcharin Loilome,
Paiboon Sithithaworn,
Anchalee Techasen,
Bandit Thinkhamrop,
Alexa Dzienny,
Ayse Caglayan,
David Park,
Simran Mahmud,
Narong Khuntikeo
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s306339
Subject(s) - medicine , opisthorchis viverrini , hazard ratio , proportional hazards model , opisthorchiasis , gastroenterology , oncology , survival analysis , cd44 , immunohistochemistry , lymphovascular invasion , cancer , pathology , immunology , confidence interval , metastasis , cell , biology , genetics , liver fluke , helminths
Opisthorchis viverrini (OV)-associated cholangiocarcinoma (CCA) has a high immune response with chronic inflammation and oxidative stress. CD44 and Nestin, two cancer stem cell (CSC) markers, play major roles in cancer cell survival. Effects of immune response and expression CSC markers on survival of patients with CCA remain unclear.