Open AccessLeptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure – Role and Functional Interplay
Author(s) -
Alexandra Dădârlat-Pop,
Dana Pop,
Lucia Maria Procopciuc,
Adela Sitar-Tăut,
Dumitru Zdrenghea,
György Bódizs,
Raluca Tomoaia,
Diana Gurzău,
Florina Frîngu,
Silvana Susca-Hojda,
Anca Dana Buzoianu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s301285
Subject(s) - medicine , heart failure , leptin , overweight , endocrinology , angiotensin ii , allele , angiotensin ii receptor type 1 , leptin receptor , obesity , cardiology , receptor , biology , gene , biochemistry
Leptin, one of the best-known adipocytes, together with the renin-angiotensin-aldosterone system and galectin-3 are important players in inflammation, arterial hypertension and heart failure pathophysiology. Moreover, uninucleotide A1166C polymorphism is associated with hypertension and poor prognosis in heart failure. The aim of the study was to investigate a possible relationship between leptin serum values, specific heart failure biomarkers and the presence of AT1 receptor A1166C polymorphism in overweight and obese heart failure patients.