Open AccessA Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota
Author(s) -
Jiaxi Zhao,
Yiqin Huang,
Xiaofeng Yu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s301141
Subject(s) - sarcopenia , gut flora , inflammation , medicine , insulin sensitivity , skeletal muscle , energy metabolism , endocrine system , immunity , bioinformatics , insulin resistance , immunology , immune system , biology , insulin , hormone
Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient nutrition, and physical inactivity. Previous studies have suggested that there is a relationship between sarcopenia and gut microbiota,namely, the gut-muscle axis. The present review highlights that the gut microbiota can affect muscle mass and muscle function from inflammation and immunity,substance and energy metabolism, endocrine and insulin sensitivity, etc., directly or indirectly establishing a connection with sarcopenia, thereby realizing the "gut-muscle axis".