Open AccessAssociation of Nuclear Factor Erythroid-2-Related Actor 2 Gene Polymorphisms with Diabetic Nephropathy in Chinese Patients
Author(s) -
Jiancheng Wang,
Man Yu,
Jianrong Chen,
Lingyan Zhu,
Jianying Liu,
Jixiong Xu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s300152
Subject(s) - medicine , diabetic nephropathy , genotype , logistic regression , type 2 diabetes mellitus , diabetes mellitus , gastroenterology , risk factor , polymorphism (computer science) , gene , genetics , endocrinology , biology
Nuclear factor erythroid-2-related factor 2 (NRF2) has emerged as a therapeutic target in many diseases. To explore this further, we evaluated the relationships between the -617C/A (rs6721961) polymorphisms within the NRF2 promoter and diabetic nephropathy (DN) in Chinese Han patients with type 2 diabetes mellitus (T2DM).