Open AccessVariants in CDHR3, CACNAC1, and LTA Genes Predisposing Sensitivity and Response to Warfarin in Patients with Cardiovascular Disease
Author(s) -
Mansour A. Alghamdi,
Laith N. AL-Eitan,
Rami Alkhatib,
Ahmad Al-Assi,
Ayah Y. Almasri,
Hanan A. Aljamal,
Hatem A Aman,
Rame Khasawneh
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s298597
Subject(s) - warfarin , medicine , vkorc1 , cyp2c9 , dosing , population , coronary artery disease , pharmacogenetics , pharmacology , gene , genotype , atrial fibrillation , biology , biochemistry , environmental health , cytochrome p450 , metabolism
Warfarin has been in use for more than 60 years; however, it has serious side effects including major bleeding. The high interpatient variability in the required dose impacts the sensitivity and responsiveness to warfarin in different patients. This study aims to assess the influence of CDHR3, CACNAC1 , and LTA gene polymorphisms on the variability of warfarin dose requirements and susceptibility to coronary heart disease in the Jordanian population.