Open AccessRisk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450, and TP53 Genes Among Nonsmokers in the Saudi Community
Author(s) -
Ikhlas A. Sindi,
Ahmed O Babalghith,
Mohammed T. Tayeb,
Ahmad H. Mufti,
Hind Naffadi,
Samar N Ekram,
Ezzeldin N. Elhawary,
Munaifah Alenezi,
Nasser A. Elhawary
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s294802
Subject(s) - medicine , gene , colorectal cancer , oncology , genetics , bioinformatics , cancer , biology
Colorectal carcinoma (CRC) represents a considerable public health burden in Saudi Arabia. Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. We explored whether allelic variants of the GSTM1, GSTT1, CYP450 (rs4646903 and rs1048943), and TP53 (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC.