Open AccessCorrelation Between Promoter Hypomethylation and Increased Expression of Syncytin-1 in Non-Small Cell Lung Cancer
Author(s) -
Yang Fu,
Xianghua Zhuang,
Xiyan Xia,
Xiaohui Li,
Xiao Ke,
Xiaojing Liu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s294392
Subject(s) - epigenetics , dna methylation , lung cancer , methylation , biomarker , promoter , cancer research , cancer , proportional hazards model , gene , cpg site , survival analysis , biology , medicine , carcinoma , adenocarcinoma , gene expression , oncology , genetics
Syncytin-1 is a human endogenous retroviral ( HERVW ) envelope protein, which has been implicated in trophoblast and cancer cell fusions as well as in immunomodulatory functions. We investigated syncytin-1 expression and promoter methylation in non-small cell lung cancer (NSCLC) and the adjacent, para-carcinoma tissues. In addition, the correlation to patient survival differentiation of between 5-year survival and death group was analyzed.