Open AccessUsefulness of Cytokine Gene Polymorphisms for the Therapeutic Choice in Japanese Patients with Rheumatoid Arthritis
Author(s) -
Saki Tsujimoto,
Yoshio Ozaki,
Tomoki Ito,
Shosaku Nomura
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s287505
Subject(s) - medicine , rheumatoid arthritis , genotype , rheumatoid factor , single nucleotide polymorphism , immunology , synovitis , autoantibody , methotrexate , arthritis , cytokine , disease , antibody , gene , genetics , biology
Rheumatoid arthritis (RA) is characterized by systemic synovitis with bone erosion and joint cartilage degradation. Although the analysis of polymorphisms in cytokine-encoding genes is important or understanding the pathophysiology of RA and selecting appropriate treatment for it, few studies have examined such single-nucleotide polymorphisms (SNPs) specifically in Japanese patients. This study was established to investigate the associations between polymorphisms in cytokine-encoding genes, autoantibodies and therapeutic responses in Japanese RA patients.