Open Access<p>Pump Proton and Laryngeal H<sup>+</sup>/K<sup>+</sup> ATPases</p>
Author(s) -
Zhe Zhang,
YangYang Bao,
ShuiHong Zhou
Publication year - 2020
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s284952
Subject(s) - gerd , laryngopharyngeal reflux , laryngitis , medicine , gastroenterology , proton pump inhibitor , reflux , atpase , proton , mucus , disease , enzyme , biochemistry , biology , physics , ecology , quantum mechanics
The presence of extra-gastric H + /K + ATPases may explain the clinically significant effect of proton pump inhibitor (PPI) pharmacotherapy in patients with chronic laryngitis related to laryngopharyngeal reflux disease (LPRD) but without gastroesophageal reflux disease (GERD) symptoms. Given the need for a better understanding of GERD and LPRD, we review the various proton pumps with respect to their classification, function, and distribution. We then consider the potential role of the laryngeal H + /K + ATPase pump in LPRD.