Open Access<p>Association of <em>GSTP1</em>, <em>GSTT1</em> and <em>GSTM1</em> Gene Variants with Coronary Artery Disease in Iranian Population: A Case–Control Study</p>
Author(s) -
Alemeh Pourkeramati,
Ehsan Zare Mehrjardi,
Masoud Dehghan Tezerjani,
Seyed Morteza Seifati
Publication year - 2020
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s252552
Subject(s) - gstp1 , genotype , odds ratio , multifactor dimensionality reduction , coronary artery disease , medicine , allele , gene , genetics , biology , single nucleotide polymorphism
Coronary artery disease (CAD) is a multifactorial disease that may be caused by the interaction between environmental and genetic risk factors. Glutathione S-transferases (GSTs) are known to participate in detoxification and metabolism of a wide range of xenobiotic compounds and oxidative stress products. Considering the interaction between environmental and genetic factors in CAD, we investigated the genetic polymorphisms of GSTM1, GSTT1 , and GSTP1 in the Iranian population.