Open AccessMutation of TonB-Dependent Receptor Encoding Gene MCR_0492 Potentially Associates with Macrolides Resistance in Moraxella catarrhalis Isolates
Author(s) -
Zhen Zhang,
Zhulan Yang,
Xiaohong Xiang,
Pu Liao,
Chunping Niu
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s364397
Subject(s) - moraxella catarrhalis , microbiology and biotechnology , gene , biology , moraxella (branhamella) catarrhalis , genetics , antibiotics , streptococcus pneumoniae
Moraxella catarrhalis , which is an opportunistic pathogen and is one of the three major pathogens of community-acquired pneumonia, causes a variety of infections in clinic. In recent years, the isolation rate of Moraxella catarrhalis has gradually increased. In China, due to the clinical empirical use of antibiotics, the resistance rate of Moraxella catarrhalis isolated from children to β-lactam antibiotics has reached 99%. The non-susceptible rate of Moraxella catarrhalis to macrolide antibiotics has also increased significantly.