Open AccessAssociation Between Types of Carbapenemase and Clinical Outcomes of Infection Due to Carbapenem Resistance Enterobacterales
Author(s) -
Korawan Pudpong,
Sutthiporn Pattharachayakul,
Wichai Santimaleeworagun,
Ozioma Forstinus Nwabor,
Varaporn Laohaprertthisan,
Thanaporn Hortiwakul,
Boonsri Charernmak,
Sarunyou Chusri
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s363588
Subject(s) - meropenem , carbapenem , colistin , medicine , carbapenem resistant enterobacteriaceae , mortality rate , cohort , antimicrobial , enterobacteriaceae infections , microbiology and biotechnology , biology , antibiotic resistance , gene , antibiotics , enterobacteriaceae , escherichia coli , genetics
Compared with non-carbapenemase producing carbapenem-resistant Enterobacterales (non-CP-CRE), carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) are associated with considerable mortality. However, given that the patients are treated with various therapeutic options, it remains unclear whether differences in types of carbapenemase genes yield different mortality rates. Therefore, this study aims to identify carbapenemase genes and identify whether clinical outcomes differ according to the prevalence of genotype and phenotype of carbapenemase among Enterobacterales clinical isolated.