Open AccessEmergence of blaOXA-1- and mph(A)-Producing Vibrio furnissii Isolated from Hospital Sewage
Author(s) -
Haishan Mo,
Xu Lin,
Ming Liu,
Hui Liang
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s363019
Subject(s) - cephalosporin , azithromycin , plasmid , microbiology and biotechnology , biology , antibiotics , strain (injury) , antibiotic resistance , drug resistance , gene , genetics , anatomy
Cephalosporins and azithromycin are clinical antibiotics used to treat infections. Co-resistance to cephalosporins and azithromycin has been observed in some Enterobacterales , but it has only rarely been reported in Vibrio species. In this study, we isolated a cephalosporin- and azithromycin-resistant V. furnissii strain, VFN3, from hospital sewage. Whole-genome sequencing results showed that the strain VFN3 possesses an IncA/C2 plasmid, pVFN3-blaOXA-193K. This conjugative plasmid carries several clinically relevant drug resistance genes, including mph (A) and bla OXA-1 . We also found that in the strain VFN3, mph (A) and bla OXA-1 are surrounded by insertion sequences and class I integrons, respectively. These data suggest that mobile elements mediate the transfer of mph (A) and bla OXA-1 . This is the first reported Vibrio species that possesses an mph (A)- and bla OXA-1 -bearing conjugative plasmid. The emergence of this conjugative multi-drug-resistance plasmid is of great concern to public health.