Open AccessSoluble Programmed Cell Death-1 is a Novel Predictor of HBsAg Loss in Chronic Hepatitis B Patients When Long-Term Nucleos(t)ide Analog Treatment is Discontinued
Author(s) -
Guichan Liao,
Ziying Liu,
Muye Xia,
Hongjie Chen,
Houji Wu,
Bing Li,
Yu Chen,
Shaohang Cai,
Xiaoyong Zhang,
Jie Peng
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s360202
Subject(s) - hbsag , chronic hepatitis , medicine , programmed cell death , virology , term (time) , gastroenterology , chemistry , apoptosis , biochemistry , hepatitis b virus , virus , physics , quantum mechanics
The immunoinhibitory receptor, programmed death 1 (PD-1), plays a critical role in immune suppression during chronic viral infection. The significance of circulating soluble PD-1 (sPD-1) in patients with chronic hepatitis B who have discontinued long-term nucleos(t)ide analog (NA) treatment remains unknown.