Open AccessPlasma and Intrapulmonary Pharmacokinetics, and Dosage Regimen Optimization of Linezolid for Treatment of Gram-Positive Cocci Infections in Patients with Pulmonary Infection After Cerebral Hemorrhage
Author(s) -
Yongli Wei,
He Zhang,
Maowu Fu,
Rui Ma,
Ronghui Li,
Lingyun Kong
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s357300
Subject(s) - linezolid , medicine , dosing , sputum , pharmacokinetics , cmax , area under the curve , regimen , enterococcus faecalis , minimum inhibitory concentration , pharmacology , pharmacodynamics , antibiotics , gastroenterology , vancomycin , microbiology and biotechnology , staphylococcus aureus , tuberculosis , biology , pathology , bacteria , genetics
The objective of this study was to perform pharmacokinetics/pharmacodynamics (PK/PD) analysis of linezolid in patients with intracerebral hemorrhage and to provide suggestions regarding dosing and treatment regimens.