Open AccessUtility of Human Neutrophil Lipocalin as a Diagnosing Biomarker of Prosthetic Joint Infection: A Clinical Pilot Study
Author(s) -
Hanjiang Liu,
Yali Yu,
Yanli Niu
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s355180
Subject(s) - medicine , biomarker , youden's j statistic , receiver operating characteristic , area under the curve , lipocalin , cohort , gastroenterology , arthroplasty , aseptic processing , prospective cohort study , surgery , biochemistry , chemistry
The discrimination of prosthetic joint infection (PJI) from aseptic failure is regarded as a major clinical challenge. The key function of human neutrophil lipocalin (HNL) in regulating bacterial infection rationalizes its potential as a biomarker to diagnose PJI. This work evaluated the accuracy of serum human neutrophil lipocalin as a biomarker to diagnose PJI.