Open AccessAntibiotic Stewardship Related to Delayed Diagnosis and Poor Prognosis of Critically Ill Patients with Vancomycin-Resistant Enterococcal Bacteremia: A Retrospective Cohort Study
Author(s) -
Yang MC,
Wu YK,
Lan Cui,
Yang MC,
Chiu SK,
Peng MY,
Su WL
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s354701
Subject(s) - bacteremia , medicine , vancomycin , daptomycin , antibiotics , enterococcus , antimicrobial stewardship , retrospective cohort study , linezolid , intensive care medicine , staphylococcus aureus , antibiotic resistance , microbiology and biotechnology , genetics , bacteria , biology
Patients with septicemia caused by vancomycin-resistant Enterococcus (VRE) bacteremia have higher mortality rates than patients infected by VSE. Vancomycin or teicoplanin is selected as the antibiotic stewardship intervention to cover methicillin-resistant Staphylococcus aureus infections before blood culture reveals VRE bacteremia in critically ill patients with Gram-positive cocci (GPC) bacteremia; this may require linezolid or daptomycin treatment instead. We thus evaluated antibiotic stewardship practices, such as appropriate timing of antibiotic use in GPC bacteremia, and clinical outcomes of critically ill patients with VRE infection.