Open AccessA New Method Based on LAMP-CRISPR–Cas12a-Lateral Flow Immunochromatographic Strip for Detection
Author(s) -
Huaming Xu,
Hao Tang,
Rongrong Li,
Zhaoxin Xia,
Wensu Yang,
Zhu Yi,
Zhen Liu,
Guoping Li,
Shenwang Ni,
Jilu Shen
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s348456
Subject(s) - crispr , loop mediated isothermal amplification , klebsiella pneumoniae , turnaround time , microbiology and biotechnology , dna , biology , computational biology , escherichia coli , computer science , genetics , gene , operating system
Carbapenemase-mediated antimicrobial resistance is currently a hot spot of global concern. Carbapenem-resistant organisms are highly prevalent in hospitals associated with difficult-to-treat infections, resulting in poor clinical outcome due to limited treatment options. It is urgently needed to have a rapid, efficient, and convenient molecular assay for identifying such resistant strains.