Open AccessMolecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India
Author(s) -
Vibhuti Rana,
Nittu Singh,
Chaitali Nikam,
Priti Kambli,
Pravin Kumar Singh,
Urmila Singh,
Amita Jain,
Camilla Rodrigues,
Charu Sharma
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s345855
Subject(s) - epidemiology , tuberculosis , molecular epidemiology , polymorphism (computer science) , gene , genetics , biology , medicine , traditional medicine , genotype , pathology
The mechanistic details of first line drug (FLD) resistance have been thoroughly explored but the genetic resistance mechanisms of second line injectables, which form the backbone of the combinatorial drug resistant tuberculosis therapy, are partially identified. This study aims to highlight the genetic and spoligotypic differences in the second line drug (SLD) resistant and sensitive Mycobacterium tuberculosis ( Mtb) clinical isolates from Mumbai (Western India) and Lucknow (Northern India).