Open AccessAn Excretory Protein of Echinococcus multilocularis Inhibits Complement Classical Pathway Activation
Author(s) -
Yiwen Qiu,
Shu Shen,
Yi Yang,
Wentao Wang
Publication year - 2022
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s344075
Subject(s) - complement system , classical complement pathway , biology , antibody opsonization , alternative complement pathway , echinococcus multilocularis , haemolysis , complement membrane attack complex , in vitro , immune system , opsonin , microbiology and biotechnology , immunology , biochemistry , echinococcosis , zoology
Alveolar echinococcosis is a lethal zoonosis caused by Echinococcus multilocularis ( E.m ) larvae. The mechanism by which E.m evades host immune attacks and ensures long-term survival remains unexplained. The complement system is a cascade of sequentially activated complement proteins that results in opsonization-related phagocytosis or membrane lysis of invading organisms. Excretory/secretory proteins (ESPs) of parasites are the main antigens that induce the immune response and play important roles in the long-term survival.