Open AccessHigh Baseline C-Reactive Protein Level Can Predict the Occurrence of the Jarisch–Herxheimer Reaction in Patients with Active Syphilis
Author(s) -
YuTing Tseng,
Pei-Yun Chou,
MingHong Tai,
ChiaYen Dai,
Susan Shin-Jung Lee,
Yao-Shen Chen,
Hung-Chin Tsai,
Yen-Hsu Chen
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s335121
Subject(s) - syphilis , medicine , penicillin , c reactive protein , primary syphilis , prospective cohort study , early syphilis , human immunodeficiency virus (hiv) , gastroenterology , cohort , immunology , secondary syphilis , antibiotics , inflammation , microbiology and biotechnology , biology
The Jarisch-Herxheimer reaction (JHR) is an inflammatory reaction that can occur after treatment for syphilis. The mechanism of JHR is unknown. The level of C-reactive protein (CRP) increases during infection and inflammation. We hypothesized that CRP may be involved in the JHR in syphilitic patients at initial syphilis infection and also through interactions with benzathine penicillin-induced phagocytosis.