Open AccessrpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis
Author(s) -
Machao Li,
Jie Lu,
Yao Lu,
Tongyang Xiao,
Haican Liu,
ShuFang Lin,
Da Xu,
Guilian Li,
Xiuqin Zhao,
Zhiguang Liu,
Lili Zhao,
Kanglin Wan
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s333433
Subject(s) - rpob , mycobacterium tuberculosis , biology , mutant , genetics , gene , tuberculosis , mutation , drug resistance , rifampicin , point mutation , microbiology and biotechnology , antibiotics , medicine , 16s ribosomal rna , pathology
To investigate the mutations within the whole rpoB gene of Mycobacterium tuberculosis and analyze their effects on rifampin (RIF) resistance based on crystal structure.