Open AccessCarbapenem-Resistant Klebsiella pneumoniae Osteomyelitis Treated with Ceftazidime-Avibactam in an Infant: A Case Report
Author(s) -
Zejuan Ji,
Keming Sun,
Zhenwei Li,
Weyland Cheng,
Junwen Yang
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s320056
Subject(s) - ceftazidime/avibactam , klebsiella pneumoniae , osteomyelitis , medicine , ceftazidime , imipenem , microbiology and biotechnology , avibactam , antibiotics , beta lactamase inhibitors , klebsiella , carbapenem , drug resistance , antibiotic resistance , surgery , biology , escherichia coli , bacteria , pseudomonas aeruginosa , biochemistry , genetics , gene
Increasing cases of carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections have been observed globally where multi-drug resistance to CR-KP can make the infection difficult to treat. In recent years, the β-lactam/β-lactamase inhibitor, ceftazidime-avibactam (CAZ-AVI), has been developed to treat complicated urinary tract infections and complicated intra-abdominal infections. CAZ-AVI is approved for children over 3-month old but has yet to be investigated for cases of osteomyelitis. Only three case reports exist in literature on the use of CAZ-AVI for CR-KP osteomyelitis in adults. In this report, we present an infant with primary hematogenous osteomyelitis and septic arthritis in the right shoulder following surgical treatment for a heart murmur. Bacterial isolation revealed a strain of CR-KP, which was successfully treated with CAZ-AVI after initial administration of imipenem-based treatments.