Open AccessTenebrio molitor as an Alternative Model to Analyze the Sporothrix Species Virulence
Author(s) -
Nancy E Lozoya-Pérez,
Laura C García-Carnero,
José A. Martínez-Álvarez,
Iván Martínez-Duncker,
Héctor M. Mora-Montes
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s312553
Subject(s) - sporothrix schenckii , virulence , biology , microbiology and biotechnology , sporothrix , sporotrichosis , immunology , genetics , gene
Sporotrichosis is an increasing threat for humans, affecting mainly skin and subcutaneous tissues but that can cause disseminated infection in immunocompromised patients. Sporothrix schenckii, Sporothrix brasiliensis , and Sporothrix globosa are the main etiological agents of this mycosis, and each species show different virulence levels. The gold standard to assess fungal virulence is the mouse model that is expensive and time-consuming. Thus, invertebrate models have been reported as an alternative for the evaluation of fungal virulence. Here, we assessed whether Tenebrio molitor larvae could be a new alternative to study Sporothrix spp. virulence.