Open AccessSynergistic Activity and Biofilm Formation Effect of Colistin Combined with PFK-158 Against Colistin-Resistant Gram-Negative Bacteria
Author(s) -
Liqiong Chen,
Kaihang Yu,
Lijiang Chen,
Xiangkuo Zheng,
Na Huang,
Yishuai Lin,
Huaiyu Jia,
Wei-Hao Liao,
Jianming Cao,
Tieli Zhou
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s309912
Subject(s) - colistin , acinetobacter baumannii , microbiology and biotechnology , klebsiella pneumoniae , biofilm , pseudomonas aeruginosa , escherichia coli , broth microdilution , bacteria , antimicrobial , acinetobacter , quorum sensing , checkerboard , biology , enterobacteriaceae , chemistry , minimum inhibitory concentration , antibiotics , biochemistry , gene , genetics
The emergence of colistin resistance among Gram-negative bacteria (GNB) poses a serious public health threat. Therefore, it is necessary to enhance the antibacterial activity of colistin through the combination with other drugs. In this study, we demonstrated the synergistic activity and the possible synergy mechanism of colistin with PFK-158 against colistin-resistant GNB, including non-fermenting bacteria and Enterobacteriaceae.