Open AccessPhenotypic and Molecular Characterization of Penicillin and Macrolide-Resistant Streptococcus pneumoniae Serotypes Among Pediatric Patients in Addis Ababa, Ethiopia
Author(s) -
Abel Abera Negash,
Daniel Asrat,
Workeabeba Abebe,
Abraham Aseffa,
Mario Vaneechoutte
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s309876
Subject(s) - streptococcus pneumoniae , penicillin , erythromycin , serotype , etest , microbiology and biotechnology , antibiotic resistance , biology , pneumococcal infections , antibiotics , macrolide antibiotics , azithromycin , virology , medicine
In several countries, introduction of the pneumococcal conjugate vaccine (PCV) has led to a decline in antimicrobial-resistant pneumococcal disease but has also resulted in a concomitant increase in antimicrobial-resistant, non-vaccine serotypes of Streptococcus pneumoniae . We sought to determine the magnitude of penicillin and macrolide resistance among pneumococcal serotypes and the mechanisms of macrolide resistance in Ethiopia, 5 years after the introduction of PCV10 in the country.