Open AccessRole of Lymphotoxin-α Gene Polymorphism in Hepatitis C Virus-Related Chronic Liver Disorders
Author(s) -
Ghada Moustafa Galal,
Hammam Tammam,
Amal Abdel Aal,
Nahed Fahmy,
Abeer Sheneef,
Nagwa Ahmed,
Amr Zaghloul
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s306879
Subject(s) - hepatocellular carcinoma , cirrhosis , genotype , lymphotoxin , medicine , gastroenterology , liver disease , lymphotoxin alpha , chronic liver disease , hepatitis c virus , genotyping , immunology , tumor necrosis factor alpha , biology , virus , gene , biochemistry
Tumor necrosis factor (TNF) family includes lymphotoxin-alpha (LTA) which is a pro-inflammatory cytokine which plays a role in hepatic fibrogenesis. LTA gene polymorphism plays a role in different inflammatory and immunomodulatory diseases. This polymorphism is also suggested to affect chronic hepatitis C (CHC) infection course.