Open AccessCeftazidime-Avibactam Resistance in Klebsiella pneumoniae Sequence Type 11 Due to a Mutation in Plasmid-Borne blakpc-2 to blakpc-33, in Henan, China
Author(s) -
Debao Li,
Keyang Li,
Han Dong,
Dongmei Ren,
Dunwei Gong,
Fuguo Jiang,
Chunhua Shi,
Junmin Li,
Qi Zhang,
Wenjuan Yan,
Yang Li
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s306095
Subject(s) - klebsiella pneumoniae , ceftazidime/avibactam , multilocus sequence typing , microbiology and biotechnology , plasmid , ceftazidime , meropenem , biology , drug resistance , antibiotic resistance , pseudomonas aeruginosa , antibiotics , genotype , escherichia coli , bacteria , genetics , gene
Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a serious problem worldwide. Herein, we describe the evolution of ceftazidime-avibactam (CZA) resistance by sequencing clinical isolates from a patient with CRKP infection undergoing CZA treatment.