Open AccessRifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies
Author(s) -
Zhen Wang,
Abulikemu Maimaitiaili,
Tengfei Wang,
Xinghua Song
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s304864
Subject(s) - in vivo , rifapentine , polylactic acid , in vitro , pharmacology , tuberculosis , drug delivery , medicine , chemistry , pathology , biochemistry , latent tuberculosis , biology , mycobacterium tuberculosis , microbiology and biotechnology , organic chemistry , polymer
Spinal tuberculosis has been a common clinical extrapulmonary tuberculosis in recent years. The general anti-tuberculosis drug treatment cycle is long, with unsatisfactory efficacy. This study focused on the preparation and evaluation of rifapentine polylactic acid sustained-release microsphere complex for spinal tuberculosis therapy.