Open AccessDifferential Prevalences of Pfmdr1 Polymorphisms in Symptomatic and Asymptomatic Plasmodium falciparum Infections in Lastoursville: A Rural Area in East-Central Gabon
Author(s) -
Steede Seinnat Ontoua,
Lady Charlène Kouna,
Sandrine Lydie OyegueLiabagui,
Dominique Fatima Voumbo-Matoumona,
Nancy Diamella Moukodoum,
Roméo Karl Imboumy-Limoukou,
Jean Bernard LekanaDouki
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s304361
Subject(s) - plasmodium falciparum , asymptomatic , differential (mechanical device) , malaria , biology , medicine , artesunate , virology , genetics , immunology , engineering , aerospace engineering
Plasmodium falciparum malaria remains a major public health challenge in sub-Saharan Africa. Plasmodium falciparum drug resistance mediated by polymorphisms in the Pfmdr1 gene contributes to the persistence of the disease on the African continent. This study investigated P. falciparum infection features and differences in the Pfmdr1 genotypes between symptomatic and asymptomatic malaria cases in a rural area in east-central Gabon.