Open AccessIn vitro Combined Inhibitory Activities of β-Lactam Antibiotics and Clavulanic Acid Against blaKPC-2-Positive Klebsiella pneumoniae
Author(s) -
Mingjia Peng,
Renru Han,
Yan Guo,
Yonggui Zheng,
Feifei Yang,
Xiaogang Xu,
Fupin Hu
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s292612
Subject(s) - clavulanic acid , meropenem , klebsiella pneumoniae , imipenem , ceftazidime , microbiology and biotechnology , broth microdilution , amoxicillin/clavulanic acid , antimicrobial , antibiotics , minimum inhibitory concentration , amoxicillin , medicine , biology , antibiotic resistance , bacteria , biochemistry , escherichia coli , genetics , gene , pseudomonas aeruginosa
The spread of KPC-producing Enterobacteriaceae has triggered a global public health concern, with KPC-2-positive strains being the most prevalent in China. We hereby studied the in vitro combined inhibitory activities of three kinds of β-lactam antibiotics and clavulanic acid at different concentrations against bla KPC-2 -positive Klebsiella pneumoniae to explore the antimicrobial characteristics of these combinations and alternative therapeutic regimens for infections caused by bla KPC-2 -positive K. pneumoniae strains.