Open AccessResistance to Second-Line Anti-TB Drugs in Cambodia: A Phenotypic and Genetic Study
Author(s) -
Sokleaph Cheng,
Mallorie Hidé,
Sok Heng Pheng,
Alexandra Kerléguer,
Gauthier Delvallez,
Sophan Sam,
Tan Eang Mao,
Thi Van Anh Nguyen,
AnneLaure Bañuls
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s289907
Subject(s) - genotype , pyrazinamide , drug resistance , extensively drug resistant tuberculosis , mycobacterium tuberculosis , biology , population , virology , multiple drug resistance , tuberculosis , medicine , genetics , gene , environmental health , pathology
Due to the emergence of Mycobacterium tuberculosis (M.tb) clinical isolates resistant to most potent first-line drugs (FLD), second-line drugs (SLD) are being prescribed more frequently. We explore the genetic characteristics and molecular mechanisms of M.tb isolates phenotypically resistant to SLD, including pre-extensively drug-resistant (pre-XDR) and extensively drug-resistant (XDR) isolates.