Open Access<p>Efflux Pump AcrAB Confers Decreased Susceptibility to Piperacillin–Tazobactam and Ceftolozane–Tazobactam in Tigecycline-Non-Susceptible <em>Klebsiella pneumoniae</em></p>
Author(s) -
Junjie Li,
Qingqing Xu,
Sean Ogurek,
Ziqiang Li,
Peiyun Wang,
Xie Quan,
Zhonghua Sheng,
Minggui Wang
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s279020
Subject(s) - tigecycline , efflux , klebsiella pneumoniae , microbiology and biotechnology , broth microdilution , tazobactam , complementation , colistin , piperacillin/tazobactam , piperacillin , biology , antibiotics , minimum inhibitory concentration , antibiotic resistance , bacteria , pseudomonas aeruginosa , gene , escherichia coli , genetics , mutant , imipenem
Drug efflux pumps are critical for resistance in Gram-negative organisms, but there are limited data on the role they play in decreased susceptibility to β-lactam/β-lactamase inhibitor combinations. In this study, we aimed to investigate the impact of efflux pump AcrAB on piperacillin-tazobactam (TZP) and ceftolozane-tazobactam (C/T) susceptibility in tigecycline-non-susceptible Klebsiella pneumoniae (TNSKP) strains.