Open Access<p>Genetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation</p>
Author(s) -
Christina Skår Saghaug,
Christian Klotz,
Juha P. Kallio,
Toni Aebischer,
Nina Langeland,
Kurt Hanevik
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s274543
Subject(s) - biology , genetics , genetic diversity , gene , allele , genome , giardia lamblia , sanger sequencing , genetic variation , loss of heterozygosity , copy number variation , dna sequencing , population , demography , sociology
The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze the genetic diversity of gFlHb in Giardia assemblages A and B clinical isolates.