Open Access<p>Prevalence of HIV-1 Integrase Strand Transfer Inhibitor Resistance in Treatment-Naïve Voluntary Counselling and Testing Clients by Population Sequencing and Illumina Next-Generation Sequencing in Taiwan</p>
Author(s) -
Hung-Chin Tsai,
I-Tzu Chen,
KuoWang Tsai,
Susan Shin-Jung Lee,
Yao-Shen Chen
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s273704
Subject(s) - integrase , genotyping , drug resistance , population , hiv drug resistance , virology , reverse transcriptase , medicine , genetics , resistance mutation , polymerase chain reaction , biology , genotype , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , gene , environmental health
Integrase strand transfer inhibitors (INSTIs) are used as first-line therapy for HIV-1-infected patients. Next-generation sequencing (NGS) can detect low-frequency mutants; however, the clinical value of NGS to detect resistance variants is unknown. This study aimed to evaluate the prevalence of INSTI resistance in southern Taiwan and determine the clinical implications of using NGS to detect integrase region low-level resistant variants.