Open Access<p>Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19</p>
Author(s) -
Xiaohan Ren,
Shangqian Wang,
Xinglin Chen,
XiaoHong Wei,
Guangyao Li,
Shancheng Ren,
Tongtong Zhang,
Xu Zhang,
Zhongwen Lü,
Zebing You,
Zengjun Wang,
Na Song,
Chao Qin
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s270543
Subject(s) - tmprss2 , biology , cytokine storm , kidney , immunology , urinary system , coronavirus , receptor , cytokine , lung , medicine , covid-19 , disease , endocrinology , genetics , infectious disease (medical specialty)
Since December 2019, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first spread quickly in Wuhan, China, then globally. Based on previously published evidence, ACE2 and TMPRSS2 are both pivotal entry molecules that enable cellular infection by SARS-CoV-2. Also, increased expression of pro-inflammatory cytokines, or a "cytokine storm," is associated with multiple organ dysfunction syndrome often observed in critically ill patients.