Open Access<p>Plasma Fibrinogen as a Diagnostic Marker of Infection in Patients with Nonunions</p>
Author(s) -
Xiangjin Wang,
Zhen Wang,
Zitao Zhang,
Xusheng Qiu,
Ming Chen,
Yixin Chen
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s269719
Subject(s) - fibrinogen , nonunion , receiver operating characteristic , medicine , erythrocyte sedimentation rate , youden's j statistic , gastroenterology , biomarker , aseptic processing , area under the curve , surgery , biology , biochemistry
The timely and accurate diagnosis of infected nonunion is challenging, and there is a need for more efficient biomarkers. Previous studies have shown that fibrinogen plays an important role in mediating inflammation in bacterial infections and, therefore, could be a valuable biomarker for infected nonunion. The purpose of this study was to evaluate and compare the performance of plasma fibrinogen and other traditional blood markers for the diagnosis of infected nonunion.