Open AccessThe Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology
Author(s) -
Yanhua Song,
Guirong Wang,
Qiang Li,
Rongmei Liu,
Li Ma,
Mengqiu Gao
Publication year - 2021
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s268799
Subject(s) - inha , rpob , ethionamide , mycobacterium tuberculosis , mutant , isoniazid , gene mutation , mutation , biology , drug resistance , genetics , gene , tuberculosis , rifampicin , medicine , antibiotics , ethambutol , 16s ribosomal rna , pathology
This study aims to analyze the correlation between gene inhA mutations by melting curve technology and phenotypic drug susceptibility (DST) results of ethionamide (ETH), and evaluate whether gene inhA mutations detection can serve as a molecular marker in predicting ETH resistance.