Open Access<p>Molecular Characterization of Hepatitis C Virus for Developed Antiviral Agents Resistance Mutations and New Insights into in-silico Prediction Studies</p>
Author(s) -
Mohamed Mohamed Adel ElSokkary,
Lizaveta Gotina,
Mohammad M. Al-Sanea,
Ae Nim Pae,
Rehab Mohammed Elbargisy
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s267809
Subject(s) - ns5b , ribavirin , genotype , virology , hepatitis c virus , sofosbuvir , biology , in silico , hepacivirus , drug resistance , mutation , virus , genetics , gene
Identification and characterization of developed antiviral drug resistance mutations are key to the success of antiviral therapies against hepatitis C virus (HCV), which remains a worldwide highly prevalent pathogenic disease. Although most studies focus on HCV genotypes 1, 2 or 3, the investigation of drug resistance in HCV genotype 4, predominant in North Africa, is especially significant in Egypt.