Open Access<p>Genetic Diversity of <em>Schistosoma haematobium</em> in Qena Governorate, Upper Egypt</p>
Author(s) -
Asmaa M El-Kady,
Mostafa I El-Amir,
Mohammed H. Hassan,
Khaled S. Allemailem,
Ahmad Almatroudi,
Alzahraa Abdelraouf Ahmad
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s266928
Subject(s) - schistosoma haematobium , praziquantel , schistosomiasis , tropical disease , genetic diversity , biology , rapd , genetic variation , veterinary medicine , schistosoma , transmission (telecommunications) , genotype , zoology , genetics , disease , medicine , helminths , gene , population , environmental health , schistosoma mansoni , electrical engineering , engineering
Schistosomiasis is an important neglected tropical disease (NTD) in several developing countries. Praziquantel is the principle and efficacious chemotherapeutic agent that has been used to treat schistosomiasis for decades. Unfortunately, emerging resistance to praziquantel with accompanying reduced efficacy is reported in some localities. Hence, genetic diversity among parasite populations is of significant interest in assessing the effects of selective pressure generated by praziquantel therapy that might result in encouraging the emergence of new genotypes that are either non-susceptible or drug-resistant. The present study aimed to investigate the genetic diversity of Schistosoma haematobium among human populations using the RAPD technique to help clarify disease epidemiology and transmission.