Open Access<p>False-Negative Serum Cryptococcal Antigen Lateral Flow Immunoassay Result for a Patient with Disseminated Cryptococcal Disease</p>
Author(s) -
Yuqiao Xu,
Wenying Xia,
Fang Ni
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s265784
Subject(s) - cryptococcus neoformans , immunoassay , dipstick , antigen , cryptococcus , cryptococcosis , immunology , microbiology and biotechnology , biology , virology , antibody , urine , biochemistry
Cryptococcus neoformans ( C. neoformans ) is an opportunistic fungal pathogen to humans, which can be acquired from environmental sources. Its most important virulence factor is its polysaccharide capsule, which can be used for diagnostic tests that identify the cryptococcal antigen (CrAg). The CrAg lateral flow assay (LFA) is a dipstick immunochromatographic assay with high sensitivity and specificity; however, several false-negative cases have been reported. Here, we present a case of a false-negative serum CrAg LFA, in which the blood culture from a matched sample was positive for C. neoformans , thus demonstrating the postzone phenomenon.