Open Access<p>Synergistic Effect and Mechanism of Plumbagin with Gentamicin Against Carbapenem-Resistant <em>Klebsiella pneumoniae</em></p>
Author(s) -
Xiuli Chen,
Liyuan Yin,
Linxiu Peng,
Yanshan Liang,
Hang Lv,
Tonghui Ma
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s265753
Subject(s) - gentamicin , klebsiella pneumoniae , plumbagin , chemistry , antimicrobial , aminoglycoside , microbiology and biotechnology , pharmacology , antibiotics , biochemistry , biology , escherichia coli , genetics , gene
Aminoglycosides are one of a few susceptible antimicrobials available for carbapenem-resistant Enterobacteriaceae (CRE). However, the altered pharmacokinetics and increasing drug resistance of aminoglycosides will make them hardly effective if used in monotherapy. The purpose of this study was to identify herbal compounds that potentiate the antibacterial effect of gentamicin against carbapenem-resistant Klebsiella pneumoniae (CRKp) with gentamicin resistance and explore the action mechanisms.