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Aminoglycosides are one of a few susceptible antimicrobials available for carbapenem-resistan Enterobacteriaceae (CRE). However, the altered pharmacokinetics and increasing drug resistance of aminoglycosides will make them hardly effective if used in monotherapy. The purpose of this study was to identify herbal compounds that potentiate the antibacterial effect of gentamicin against carbapenem-resistan Klebsiella pneumoniae (CRKp) with gentamicin resistance and explore the action mechanisms.

infection and drug resistance

&lt;p&gt;Synergistic Effect and Mechanism of Plumbagin with Gentamicin Against Carbapenem-Resistant &lt;em&gt;Klebsiella pneumoniae&lt;/em&gt;&lt;/p&gt;