Open Access<p>Cysteine Potentiates Bactericidal Antibiotics Activity Against Gram-Negative Bacterial Persisters</p>
Author(s) -
Yuan Lv,
Kangni Yang,
Yuqian Jia,
Jingru Shi,
Ziwen Tong,
Zhiqiang Wang
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s263225
Subject(s) - bacteria , cysteine , antibiotics , microbiology and biotechnology , chemistry , bacterial cell structure , bacterial growth , biology , biochemistry , enzyme , genetics
Bacterial metabolism regulators offer a novel productive strategy in the eradication of antibiotic refractory bacteria, particularly bacterial persisters. However, the potential of amino acids in the fight against Gram-negative bacterial persisters has not been fully explored. The aim of this study is to investigate the potentiation of amino acids to antibiotics in combating Gram-negative bacterial persisters and to reveal the underlying mechanisms of action.