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Staphylococcus aureus produces numerous toxins, such as toxic shock syndrome toxin 1 (TSST-1) and Panton-Valentine leukocidin (PVL). We isolated community-acquired methicillin-resistan Staphylococcus aureus (CA-MRSA) strains producing both TSST-1 and PVL isolated from severe necrotizing pneumonia cases in a Nepali family. Detection of these CA-MRSA strains is rare in the world, and infection with these strains can take a rapidly progressive and lethal course. In this study, we traced the clinical course of this case and conducted a genetic analysis of the isolated strains.

infection and drug resistance

&lt;p&gt;Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt; Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis&lt;/p&gt;