Open Access<p>Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant <em>Staphylococcus aureus</em> Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis</p>
Author(s) -
Katsura Hayakawa,
Tetsuo Yamaguchi,
Daisuke Ono,
H. Suzuki,
Jiro Kamiyama,
Shigemasa Taguchi,
Kazuya Kiyota
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s262123
Subject(s) - leukocidin , staphylococcus aureus , medicine , panton–valentine leukocidin , sccmec , methicillin resistant staphylococcus aureus , pneumonia , toxic shock syndrome , microbiology and biotechnology , antibiotics , biology , bacteria , genetics
Staphylococcus aureus produces numerous toxins, such as toxic shock syndrome toxin 1 (TSST-1) and Panton-Valentine leukocidin (PVL). We isolated community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains producing both TSST-1 and PVL isolated from severe necrotizing pneumonia cases in a Nepali family. Detection of these CA-MRSA strains is rare in the world, and infection with these strains can take a rapidly progressive and lethal course. In this study, we traced the clinical course of this case and conducted a genetic analysis of the isolated strains.