Open Access<p>Synergistic Effect of Pseudolaric Acid B with Fluconazole Against Resistant Isolates and Biofilm of <em>Candida tropicalis</em></p>
Author(s) -
Zhen Li,
Hang Yin,
Weiqin Chen,
Cen Jiang,
Jun Hu,
Yingjun Xue,
Dongting Yao,
Yibing Peng,
Xiaobo Hu
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s261299
Subject(s) - biofilm , microbiology and biotechnology , candida tropicalis , minimum inhibitory concentration , biology , fluconazole , broth microdilution , bacteria , chemistry , antifungal , antimicrobial , genetics
Candida tropicalis ( C. tropicalis ) has emerged as an important fungal pathogen due to its increasing resistance to conventional antifungal agents, especially fluconazole (FLC). Pseudolaric acid B (PAB), a herbal-originated diterpene acid from Pseudolarix kaempferi Gordon, has been reported to possess inhibitory activity against fungus. The present study aims to investigate the antifungal effect of PAB alone and in combination with FLC on planktonic and biofilm cells of C. tropicalis .