Open Access<p>Pyrazinamide Resistance and Mutation Patterns Among Multidrug-Resistant <em>Mycobacterium tuberculosis</em> from Henan Province</p>
Author(s) -
Jie Shi,
Ru-yue Su,
Danwei Zheng,
Yuxian Zhu,
Xiaolong Ma,
Shaohua Wang,
Hui Li,
Dingyong Sun
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s260161
Subject(s) - pyrazinamide , mycobacterium tuberculosis , mutation , multiple drug resistance , biology , drug resistance , genotype , tuberculosis , point mutation , microbiology and biotechnology , gene , genetics , medicine , pathology
This study was designed to identify the phenotypic and genotypic characteristics of pyrazinamide (PZA) resistance among multidrug-resistant Mycobacterium tuberculosis (MDR-TB) from Henan and to evaluate the efficacy of pncA, rpsA , and panD mutations in predicting PZA resistance.