Open Access<p>iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-Producing <em>Klebsiella pneumoniae</em></p>
Author(s) -
Yan Wang,
Shan Cong,
Qinghua Zhang,
Ranwei Li,
Ke Wang
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s259894
Subject(s) - klebsiella pneumoniae , virulence , microbiology and biotechnology , biology , klebsiella , pathogen , enterobacteriaceae , gene , escherichia coli , genetics
Treatment of infections with Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases (ESBLs) is challenging due to the coexistence of multiple resistance mechanisms and the hypervirulent variant. Therefore, new targets or more effective treatment options aimed at ESBL-producing Klebsiella pneumoniae are urgently needed.