Open Access<p>In-vitro Investigation of Antibiotics Efficacy Against Uropathogenic <em>Escherichia coli</em> Biofilms and Antibiotic Induced Biofilm Formation at Sub-Minimum Inhibitory Concentration of Ciprofloxacin</p>
Author(s) -
Zara Rafaque,
Nasira Abid,
Nida Liaqat,
Pashmina Afridi,
Saima Siddique,
Safia Masood,
Sehrish Kanwal,
Javid Iqbal Dasti
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s258355
Subject(s) - biofilm , microbiology and biotechnology , ciprofloxacin , antibiotics , virulence , fimbria , escherichia coli , norfloxacin , biology , minimum inhibitory concentration , levofloxacin , bacteria , biochemistry , genetics , gene
Community-acquired urinary tract infections are associated with significant morbidity, and uropathogenic Escherichia coli (UPEC) alone causes 90% of urinary tract infections. This bacterium retains a diverse armament of virulence factors including fimbria, hemolysins, and siderophores production. In a post invasion scenario, formation of intracellular communities mimic biofilm-like characteristics and are linked to recurrent urinary tract infections. We investigated the effects of different frontline antibiotics on the formation, inhibition, and eradication of biofilms of virulent UPEC strains.