Open Access<p>Genetic and Virulence Characteristics of Linezolid and Pretomanid Dual Drug-Resistant Strains Induced from <em>Mycobacterium tuberculosis</em> in vitro</p>
Author(s) -
Minghao Hu,
Ling Fu,
Bin Wang,
Jian Xu,
Shaochen Guo,
Jianjun Zhao,
Yuanyuan Li,
Xiaoyou Chen,
Yu Lu
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s257145
Subject(s) - virulence , linezolid , microbiology and biotechnology , mutant , mycobacterium tuberculosis , biology , drug resistance , mycobacterium , genotype , in vitro , gene , tuberculosis , virology , bacteria , genetics , medicine , staphylococcus aureus , pathology , vancomycin
Linezolid (LZD) and pretomanid (PA-824) are promising candidates in regimens for the treatment of drug-resistant tuberculosis. However, research on LZD and PA-824 dual drug-resistant (LPDR) strains is rarely reported. This study aimed to investigate the genotypic and virulence characteristics of LPDR strains.