Open Access<p>Treatment Failure in Urinary Tract Infections: A Warning Witness for Virulent Multi-Drug Resistant ESBL- Producing <em>Escherichia coli</em></p>
Author(s) -
Zahra Naziri,
Abdollah Derakhshandeh,
Arash Soltani Borchaloee,
Meisam Poormaleknia,
Negar Azimzadeh
Publication year - 2020
Publication title -
infection and drug resistance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 39
ISSN - 1178-6973
DOI - 10.2147/idr.s256131
Subject(s) - virulence , microbiology and biotechnology , antibiotics , biology , sulfamethoxazole , escherichia coli , antibiotic resistance , trimethoprim , tetracycline , drug resistance , penicillin , cephalosporin , bacterial adhesin , gene , biochemistry
Global increase in the prevalence of virulent extended-spectrum beta-lactamase (ESBL)-producing uropathogenic Escherichia coli (UPEC), which is also multi-drug resistant (MDR), leads to increase in severity of urinary tract infections (UTIs), decrease in the efficacy of the first-line antibiotics, and therefore increase in the morbidity and mortality rates.